TREATMENT REGIMEN USING CANCER VACCINES AND LOCAL ADJUVANTS AND THEIR USE

摘要

The present invention provides compositions and methods for locally administering an adjuvant following HPV vaccine compositions such as CRT/E7 DNA vaccine administration, on antigen-specific CD8+ T cell-mediated immune responses and antitumor effects for use in treating HPV-related disease. In some embodiments, the present invention provides compositions and methods for treatment of HPV-related disease comprising administering immunological compositions followed by administration of an adjuvant, such as the toll-like receptor 7 agonist, imiquimod.