Immunogenic composition against Campylobacter jejuni

摘要

The inventive subject matter relates to an immunogenic composition against Campylobacter jejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacter jejuni strains. The inventive subject matter also relates to methods of using the polysaccharide compositions in inducing and anti-C. jejuni immune response.

主权项

1. An immunogenic composition against Campylobacter jejuni, comprising one or more polysaccharide antigens, wherein each polysaccharide antigen comprises an isolated Campylobacter jejuni capsule polysaccharide, derived from a C. jejuni strain, linked to form a repeating polysaccharide polymer comprising 1 to 100 polysaccharides, wherein said Campylobacter jejuni strains are selected from the group consisting of: HS1, HS1/HS44, HS44, HS2, HS3, HS4, HS5, HS13, HS4/13/64, and HS50, and wherein said composition does not contain lipooligosaccharide structures and other structures associated with Guillain Barré Syndrome.