Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof

摘要

The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative.

主权项

1. A method for inhibiting the ATPase activity without stimulating the receptor function of Na/K-ATPase in a cell in need thereof, comprising:
administering an effective amount of at least one Na/K-ATPase ligand comprising at least one hydroxyl xanthone derivative having the structure: wherein one or more of R1, R3, R4, R5 and R6 are selected from H, OH, OCH3, carboxylic acid ester, or analog thereof.