发明名称 INTERCONNECTED BIOREACTORS
摘要 A method of homogenously mixing the contents of a plurality of bioreactors by providing a receiving container capable of holding an appropriate quantity of the liquid and repeatedly raising and lowering the receiving container to a position above or below the position of the bioreactors resulting in mixing the contents of the bioreactors.
申请公布号 US2015275318(A1) 申请公布日期 2015.10.01
申请号 US201514738399 申请日期 2015.06.12
申请人 Niazi Sarfaraz K. 发明人 Niazi Sarfaraz K.
分类号 C12Q3/00 主分类号 C12Q3/00
代理机构 代理人
主权项 1. A method of homogenously mixing the contents of a plurality of bioreactors comprising: a. providing a hard platform to support a plurality of bioreactors; b. providing a fulcrum stand to support the hard platform and allow movement of the hard platform to a pre-determined angle on either side of the stand, wherein the platform is capable of being raised or lowered; c. installing a plurality of bioreactors, 1 though n, in a series on the hard platform, wherein each bioreactor comprises at least two liquid ports wherein the port comprises a valve for opening or closing the port and at least one sensor, wherein the sensor is capable of measuring the weight of the bioreactor; d. connecting one liquid port of the first bioreactor in the series of bioreactors to one liquid port of the next bioreactor in the series, and continuing the connectivity till the nth bioreactor in the series is connected; e. closing the second liquid port of the first bioreactor and the second liquid port of the nth bioreactor; f. raising the hard platform at one end to a sufficient height to allow flow of the liquids of the bioreactors across all bioreactors; g. measuring the increase in the weight of the nth bioreactor to a pre-determined level; h. lowering the same end of the hard platform to the same degree as the platform was raised in step (f); i. measuring the increase in the weight of the first bioreactor to a pre-determined level; and j. repeating steps (e) to (i) periodically or continuously.
地址 Deerfield IL US