发明名称 |
THERAPEUTIC OR PROPHYLACTIC AGENT FOR RETINOPATHY OF PREMATURITY, TESTING METHOD FOR RETINOPATHY OF PREMATURITY, AND SCREENING METHOD FOR THERAPEUTIC OR PROPHYLACTIC SUBSTANCE FOR RETINOPATHY OF PREMATURITY |
摘要 |
Provided are a therapeutic or prophylactic agent for retinopathy of prematurity (ROP) that is suited to the pathogenic mechanism of ROP and a method of testing for ROP. The therapeutic or prophylactic agent for ROP uses at least one substance from the group consisting of inhibitors against tryptase derived from mast cells and/or mast cell stabilizers as an active ingredient. The testing method for ROP includes detecting a marker substance that can be released by degranulation of mast cells in a biological sample originating from a patient and determining the presence or absence of ROP on the basis of the detected amount of the marker. |
申请公布号 |
US2015276718(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
US201314437925 |
申请日期 |
2013.10.24 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD. ;TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY |
发明人 |
Matsuda Hiroshi;Tanaka Akane |
分类号 |
G01N33/50;G01N33/573;C07K16/40 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
1. A therapeutic or prophylactic agent for retinopathy of prematurity comprising at least one compound selected from the group consisting of: inhibitors against tryptase derived from mast cells; and mast cell stabilizers as an active ingredient. |
地址 |
Osaka-shi, Osaka JP |