发明名称 |
PROCESS FOR PREPARATION OF ROFLUMILAST |
摘要 |
The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc:;;In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided. |
申请公布号 |
US2015274667(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
US201514736062 |
申请日期 |
2015.06.10 |
申请人 |
SCINOPHARM (CHANSHU) PHARMACEUTICALS, LTD. |
发明人 |
Chen Yi-Jing;Pikul Stanislaw;Kuo Shen-Chun;Chu Guo-dong |
分类号 |
C07D213/74;C07D319/06;C07D317/22;C07C43/307 |
主分类号 |
C07D213/74 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of formula Vc:wherein
R1 and R2 are independently selected from the group consisting of H; C1-6 alkyl; C3-7 cycloalkyl; C3-7 cycloalkylmethyl; and C1-4 alkyl which is partially or completely substituted with fluorine. |
地址 |
Changsu CN |