| 主权项 |
1. Compounds of formula (I) wherein Z is a bond, alkylene, or alkenylene, wherein alkylene and alkenylene are optionally substituted with one, two or three substituents selected independently from the list of halo, cyano, hydroxy, and alkoxy; R1 is aryl or heteroaryl, wherein each is optionally substituted with one, two or three substituents selected independently from the list of halo, cyano, alkyl, haloalkyl, hydroxyalkyl, alkoxy and haloalkoxy; R2 is hydrogen, alkyl, haloalkyl, cyanoalkyl, or hydroxyalkyl; R3 is saturated or partially unsaturated heterocycloalkyl which is substituted with one, two, three or four R4; R4 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, hydroxy, alkoxy, oxo, —C(O)—R5, or —S(O)2—R6; wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and alkoxy are optionally substituted by one, two or three R7; R5 is hydrogen, alkyl, haloalkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxy, or alkoxy; R6 is hydrogen, alkyl, haloalkyl, cyanoalkyl, hydroxyalkyl, alkoxyalkyl, cycloalkyl, aryl, haloaryl, heteroaryl or alkylheteroaryl; R7 is halo, haloalkyl, cyano, hydroxy, alkoxy, cycloalkyl, heterocycloalkyl, aryl or —C(O)O-alkyl; and pharmaceutically acceptable salts and esters thereof. |
