发明名称 |
SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS |
摘要 |
<p>The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives of formula (I) and also compounds of formula (I') wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.</p> |
申请公布号 |
WO2015144801(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
WO2015EP56501 |
申请日期 |
2015.03.26 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
MEVELLEC, LAURENCE, ANNE;JEANTY, MATTHIEU, LUDOVIC;JOUSSEAUME, THIERRY, FRANÇOIS, ALAIN, JEAN |
分类号 |
C07D487/04;A61K31/519;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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