| 发明名称 |
Modification of Allergens for Immunotherapy |
| 摘要 |
The present invention relates to pharmaceutical compositions for immunotherapy, for example for immunotherapy of peanut allergy. Further, the present invention relates to methods for the preparation of the present pharmaceutical compositions for immunotherapy, and their use in immunotherapy.;Furthermore, the present invention relates to processes for modifying allergens thereby enhancing their application in immunotherapy. The invention also relates to the present modified allergens and pharmaceutical compositions comprising the present allergens, as well as to the use thereof in immunotherapy.;According to a particularly preferred embodiment, the present invention relates to pharmaceutical compositions for immunotherapy comprising reduced and alkylated naturally occurring peanut allergens Ara h2 and/or Ara h6, or derivates or isoforms thereof wherein said pharmaceutical composition substantially does not comprise Ara h1 and/or Ara h3. |
| 申请公布号 |
US2015273052(A1) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201514637198 |
申请日期 |
2015.03.03 |
| 申请人 |
HAL ALLERGY HOLDING B.V. |
发明人 |
KOPPELMAN Stefan Johan;VAN DEN HOUT Robertus Henricus Joannes Alfonsus;SLEIJSTER-SELIS Henriette Emilie;LUIJKX Dionisius Marinus Antonius Maria |
| 分类号 |
A61K39/35;A61K39/39;A61K36/48 |
主分类号 |
A61K39/35 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for immunotherapy treatment comprising administering a pharmaceutical composition comprising reduced and alkylated naturally occurring Ara h2 and Ara h6, or derivates or isoforms thereof to an allergic patient in need thereof in a pharmaceutically effective dose;
wherein said pharmaceutical composition substantially does not comprise Ara h1 and/or Ara h3. |
| 地址 |
CH Leiden NL |
