METHOD AND KIT FOR PROGNOSIS OF OPA1 GENE INDUCED DISEASES, E.G. KJERS OPTIC ATROPHY.

摘要

The present invention provides the use of the activity or expression level of Nuclear factor (erythroid -derived 2)-like 2 (NRF2)-activated genes products, e.g. SOD1 and CAT, in the prognosis of an OPA1 gene- or OPA1 gene product- deficit-induced disease, e.g. optic atrophy and optic neuropathy, or related complications by detecting expression or activity in a biological sample selected from fibroblasts, epithelial cells, blood samples or a mixture thereof, of a patient affected or suspected to be affected by said disease.