METHOD FOR QUICK-SEARCH OF LOCI-OF-INTEREST IN A GENE SEQUENCE OF A TARGET BIOLOGICAL VIRUS

摘要

In a method for quick-search of loci-of-interest in a gene sequence of a target biological virus, a computer executes a phylogenetic algorithm to generate phylogenetic tree information, which is generated based on a selected gene segment of the target biological virus and a corresponding gene segment of each of related biological viruses. A set of to-be-matched biological viruses is determined based on the phylogenetic tree information. A computer matches the gene sequences of the to-be-matched biological viruses in the set so as to find the loci-of-interest in the gene sequence of the target biological virus.

主权项

1. A computer-implemented method for quick-search of loci-of-interest in a gene sequence of a target biological virus, the computer-implemented method comprising:
A) finding a set of to-be-matched biological viruses from a group of related biological viruses that are related to the target biological virus, including
a1) generating phylogenetic tree information using at least one computer that executes at least one phylogenetic algorithm, the phylogenetic tree information being generated based on at least one selected gene segment of the gene sequence of the target biological virus and a corresponding at least one gene segment of a gene sequence of each of the related biological viruses in the group, the corresponding at least one gene segment corresponding to the at least one selected gene segment, anda2) determining the set of to-be-matched biological viruses based on the phylogenetic tree information thus generated; and B) matching, using a computer, the gene sequences of the to-be-matched biological viruses in the set so as to find the loci-of-interest in the gene sequence of the target biological virus.