The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
申请公布号
WO2015148854(A1)
申请公布日期
2015.10.01
申请号
WO2015US22841
申请日期
2015.03.26
申请人
VANDERBILT UNIVERSITY
发明人
LEE, TAEKYU;BIAN, ZHIGUO;BELMAR, JOHANNES;CHRISTOV, PLAMEN P.;PELZ, NICHOLAS F.;SHAW, SUBRATA;KIM, KWANGHO;TARR, JAMES C.;OLEJNICZAK, EDWARD T.;ZHAO, BIN;FESIK, STEPHEN W.
