METHOD OF PREPARING PHARMACEUTICAL BY CONTINUOUS FLOW MULTI-STAGE REACTION

摘要

PROBLEM TO BE SOLVED: To obtain optic active compounds efficiently by incorporating, into a multi-stage flow synthesis system, a column provided with a solid-phase synthesis device necessary for synthesizing optic active compounds to become pharmaceuticals or synthetic intermediate thereof and a column provided with a solid-phase synthesis device necessary for a functional group conversion.SOLUTION: In a multi-stage flow synthesis device as shown in the following figure, the above problem is solved by using a multi-stage synthesis device in which two kinds of flow synthesis columns such as a column A filled with chiral ligand and metal salt for obtaining an optic active compound, and a column B, which is necessary for a functional group conversion, filled with a solid-phase catalyst for performing hydrogenation reaction are connected in series according to the number of necessary processes to pass through reaction substrate.