发明名称 DYES FOR LABELLING MOLECULAR LIGANDS
摘要 Cyanine dyes with improved fluorescence intensity and photostability.
申请公布号 US2015274976(A1) 申请公布日期 2015.10.01
申请号 US201514737386 申请日期 2015.06.11
申请人 ILLUMINA CAMBRIDGE LIMITED 发明人 ROMANOV Nikolai;ANASTASI Carole;LIU Xiaohai
分类号 C09B23/01 主分类号 C09B23/01
代理机构 代理人
主权项 1. A compound of formula I or mesomers thereof: wherein CI is a charge balancing counterion and p is an integer from 1-7; m is 1, 3, 5, 7, or 9; each incidence of X is independently hydrogen, halogen, alkyl- or aryloxy, alkyl- or arylthio, amino- or substituted amino, aryl or alkyl, any of which may be optionally substituted with a substituent selected from carboxyl, sulfonate, sulfinate, sulfoxide, sulfone, sulfonamide, hydroxyl, amino, alkyl- or aryl-amino, dialkyl(aryl)amino, alkoxy, aryloxy, alkyl- or arylthio and halogen; optionally, one or more X groups are combined to form a cyclic ring; Y is independently selected from O, NRa, S, Se, CRb═CRc or CR2R3; Z is independently selected from O, NRa, S, Se, CRb═CRc or CR4R5; wherein Ra,b,c, R2, R3, R4, and R5 are independently selected from hydrogen, halogen, alkyl- or aryloxy, alkyl- or arylthio, amino- or substituted amino, alkyl, aryl or substituted alkyl, substituted aryl like carboxyaryl, or sulfoaryl; R1 is selected from aryl or alkyl, any of which may be optionally substituted with at least one substituent selected from carboxyl, sulfonate, sulfinate, sulfoxide, sulfone, sulfonamide or substituted sulfonamide, hydroxyl, amino, alkyl(aryl)amino, dialkyl(aryl)amino, alkoxy, halogen, succinimidyl ester, ester, and amide or substituted amide; R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 are independently selected from carboxyl, sulfonate, sulfinate, sulfoxide, sulfone, sulfonamide, hydroxyl, amino, alkylamino, dialkylamino, alkoxy, halogen, alkyl succinimidyl ester, ester, amide, or any ortho-disposed pair of R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18 is combined to form a further fused aromatic or heterocyclic ring that is optionally substituted; wherein at least one of R14, R15, R16, R17, or R18 is sulfonate or a further fused ring derived from R14, R15, R16, R17, or R18 comprises at least one sulfonate substituent; with the proviso that none of R14, R15, R16, R17, and R18 are carboxyl.
地址 Essex GB