Disulfide Stabilised Antibodies and Fragments Thereof

摘要

The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.

主权项

1. An antibody or antibody fragment comprising at least one Fab molecule, wherein the Fab molecule comprises one or more disulfide bonds present between variable domains of heavy and light chain pairing therein.