GLP-1 ANALOGUE, ITS PREPARATION METHODS AND USE THEREOF

摘要

Provided is a GLP-1 analogue having the structure as shown in the general formula A:;7HAEX10TFTSX15VSSYLEX22QAAKEFIX30WLX33KGRG37n1X1Cn2X2   (general formula A),;wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine, X1 and X2 respectively is glycine, alanine or valine, n1=1-30, n2=1-30. The general formula A contains two cysteines to form disulfide bonds. Also provided are the preparation methods and the use of said GLP-1 analogue. Said GLP-1 analogue has a prolonged blood half-life compared with GLP-1, and can be used for the treatment of diabetes and obesity.

主权项

1. A GLP-1 analogue having the following general formula A:
7HAEX10TFTSX15V SSYLE X22QAAK EFIX30W LX33KGR G37n1X1C n2X2   General Formula A, wherein X10 is glycine or cysteine, X15 is aspartic acid or cysteine, X22 is glycine or cysteine, X30 is alanine or cysteine, X33 is valine or cysteine, and at least one of X10, X15, X22, X30 and X33 is cysteine; n1X1 means that the number of X1 is n1, n1=1-30, and X1 is glycine, alanine or valine; n2X2 means that the number of X2 is n2, n2=0-30, and X2 is glycine, alanine or valine; and both of the two cysteines contained in the general formula A form disulfide bonds.