| 发明名称 |
A RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL |
| 摘要 |
The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids. |
| 申请公布号 |
US2015276719(A2) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201214367061 |
申请日期 |
2012.12.19 |
| 申请人 |
Beekman Jeffrey Matthijn;Dekkers Johanna Florentia;Van Der Ent Cornelis Korstiaan;Clevers Johannes C. |
发明人 |
Beekman Jeffrey Matthijn;Dekkers Johanna Florentia;Van Der Ent Cornelis Korstiaan;Clevers Johannes C. |
| 分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An in vitro method for studying the effectiveness of one or more drugs for treating cystic fibrosis, polycystic kidney disease or cholera, wherein the method comprises stimulation of one or more cystic fibrosis, polycystic kidney disease or cholera organoids generated from primary cells with said one or more drugs and measuring swelling of the one or more organoids, wherein swelling means a change in size of the one or more organoids due to fluid uptake or secretion. |
| 地址 |
CM Utrecht NL |
