COMPOSITIONS AND METHODS FOR MODULATING NCOA4-MEDIATED AUTOPHAGIC TARGETING OF FERRITIN
摘要
Described herein are methods of modulating autophagic targeting of ferritin in a cell, wherein the method comprises modulating the level and/or activity of nuclear receptor coactivator 4 (NCOA4) in the cell. Also provided are related methods of treatment.
申请公布号
WO2015149006(A2)
申请公布日期
2015.10.01
申请号
WO2015US23142
申请日期
2015.03.27
申请人
DANA-FARBER CANCER INSTITUTE, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;BETH ISRAEL DEACONESS MEDICAL CENTER, INC.;BRIGHAM & WOMEN'S HOSPITAL, INC.
发明人
KIMMELMAN, ALEC C.;MANCIAS, JOSEPH D.;HARPER, JEFFREY WADE
