吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用;PYRAZOLOPYRIMIDINONE OR PYRROLOTRIAZINONE DERIVATIVES, PREPARATION METHOD AND MEDICAL USE THEREOF

摘要

本发明涉及吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物、其制备方法及其在医药上的应用。具体而言，本发明涉及一种通式(I)所示的吡唑并嘧啶酮类或吡咯并三嗪酮类衍生物及其可药用的盐，其制备方法以及它们作为促性腺素释放激素(GnRH)受体拮抗剂特别是作为子宫内膜异位症等治疗剂的用途，其中通式(I)中的各取代基的定义与说明书中的定义相同。;The present invention relates to pyrazolopyrimidinone or pyrrolotriazinone derivatives, the preparation method and medical use thereof. Specifically, the present invention relates to a novel pyrazolopyrimidinone or pyrrolotriazinone derivative represented by formula (I), the preparation methods thereof, the pharmaceutical composition containing the same, the use of the same as a gonadotropin-releasing hormone (GnRH) receptor antagonist, especially the uses for treatment of endometriosis disease, wherein each substituent of formula (I) is as defined in the specification.