| 发明名称 |
METHOD FOR CELL DIFFERENTIATION |
| 摘要 |
The present invention relates to the field of cell biology, in in particular to methods for differentiating pluripotent stem cells. The invention provides methods for differentiating primate pluripotent stem cells into cells of all three germinal layers. In particular, methods for differentiating primate pluripotent stem cells into the definitive endoderm are provided. |
| 申请公布号 |
US2015275178(A1) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201414225740 |
申请日期 |
2014.03.26 |
| 申请人 |
GE HEALTHCARE UK LIMITED |
发明人 |
CZYSZ KATARZYNA ANNA |
| 分类号 |
C12N5/071;G01N33/569;G01N33/50;C12N5/0735 |
主分类号 |
C12N5/071 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing definitive endoderm (DE) cells from primate pluripotent stem cells (pPSC) comprising culturing the pPSC in a medium comprising Activin A and a dimethyl sulfoxide (DMSO), thereby producing DE cells that express a gene selected from the group consisting of SOX17, CXCR4 and GATA4. |
| 地址 |
LITTLE CHALFONT GB |
