UNIVERSAL INFLUENZA VACCINE BASED ON HETEROLOGOUS MULTIPLE M2E PROTEINS

摘要

Disclosed are universal influenza A vaccines capable of providing broader crossprotection. The vaccine contains a fusion protein comprising tandem repeats of heterologous M2e epitope sequences that have been molecularly and genetically designed to provide broad cross-protection. The fusion protein may be incorporated into virus-like particles (VLPs) or a replicating live attenuated influenza virus vaccine, and administered alone or in combination with other influenza vaccines.

主权项

1. A cross-protective influenza vaccine comprising a fusion protein immobilized on the surface of a virus-like particle (VLP) or in a secreted form,
wherein the fusion protein comprises tandem repeats of three or more heterologous influenza virus matrix protein 2 extracellular (M2e) domains, and wherein the vaccine is cross-protective against two or more subtypes of influenza A with or without the use of an adjuvant.