METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT

摘要

Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.

主权项

1. A method for enhancing hematopoietic cell engraftment in a subject following hematopoietic cell transplantation, the method comprising: administering to a subject following hematopoietic cell transplantation a therapeutically effective amount of a compound selected from the group consisting of: S-farnesyl-L-cysteine methyl ester (FCME), and farnesylthioacetic acid (FTA),
wherein the level of engraftment of said hematopoietic cells in said subject treated with S-farnesyl-L-cysteine methyl ester (FCME), and/or farnesylthioacetic acid (FTA) is increased compared to engraftment of a population of hematopoietic cells in an untreated subject.