DEVICE AND METHOD FOR PREPARING AND ADMINISTERING ONE-COMPONENT FIBRIN SEALANT

摘要

Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container, the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed disposed within a vessel, the vessel capable of being in fluid communication with the container, wherein when in fluid communication, passage of the mixture through the vessel results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.

主权项

1. A device for preparing and delivering fibrin sealant to a surface, the device comprising:
a. a syringe comprising a barrel and a plunger, wherein the barrel contains a quantity of a cell-free liquid mixture comprising:
I. fibrin orII. fibrinogen and Factor II; and b. a resin bed disposed within a vessel such that when an interior of the syringe barrel is in fluid communication with the resin bed, expulsion of the mixture from the barrel by the plunger forces the mixture to pass through the resin bed within the vessel resulting in (i) reduction in a concentration of an inhibitor(s) of fibrin clot formation within the mixture and/or (ii) increase in a concentration of an inducer(s) of fibrin clot formation within the mixture, wherein
(A) following the passage through the vessel, a fibrin clot is formed with a clotting time (TCLOT) of at most 1 hour at an ambient temperature selected from the group consisting of 21° C., 22° C., 23° C., 24° C., and 25° C.; and(B) the inhibitor(s) and the inducer(s) are small molecules.