DOSAGE FORMS COMPRISING APIXABAN AND MATRIX FORMER

摘要

The invention relates to oral dosage forms for modified release of apixaban. The invention also relates to methods of preparing said dosage forms and to an agglomerated mixture of matrix former and filler for preparing an oral dosage form for use in the treatment of venous thromboembolism.

主权项

1. Oral dosage form for modified release containing
a) particulate, crystalline apixaban and b) matrix former, wherein preferably the apixaban particle size distribution has a D50-value of 5 to 500 μm, and wherein the matrix former is selected from cellulose ether, cellulose ester, starch, gum, shellac, fatty substances, polyvinylchloride, polyvinyl alcohol polyvinyl acetate or copolymers thereof, polymers based on acrylic acid and/or methacrylic acid and ionic exchange resins.