| 主权项 |
1. A compound of formula (I): wherein
R1 represents —CF3; a linear or branched C1-C6 alkyl; a linear or branched C2-C6 alkenyl; a linear or branched C2-C6 alkynyl; a linear or branched fluoroalkyl; a C3-C6 cycloalkyl, CH2OH or —CH2—O—CH3;R2, non-substituted or substituted by at least one T′, represents a linear or branched C2-C8 alkyl; a linear or branched C2-C8 alkenyl; a linear or branched C2-C8 alkynyl; a linear or branched C1-C8 heteroalkyl; a linear or branched C2-C8 heteroalkenyl; a linear or branched C2-C8 heteroalkynyl; a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle; a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle fused with a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle; a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle fused with a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle; a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; a C1-C8 alkyl-(saturated, partially or totally unsaturated or aromatic C3-C7 carbocycle); a C1-C8 alkenyl-(saturated, partially or totally unsaturated or aromatic C3-C7 carbocycle); a C1-C8 heteroalkyl-(saturated, partially or totally unsaturated or aromatic C3-C7 carbocycle); a C1-C8 alkyl-(saturated, partially or totally unsaturated or aromatic C4-C7 heterocycle); a C1-C8 heteroalkyl-(saturated, partially or totally unsaturated or aromatic C4-C7 heterocycle); a bicyclo[2.2.1]heptane; a bicyclo[2.2.1]heptene; a bicyclo[2.2.2]octane; or a bicyclo[2.2.2]octene;R3, non-substituted or substituted by at least one T2, represents an aryl; an aryl fused with a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle; an aryl fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; a heteroaryl; a heteroaryl fused with a saturated, partially or totally unsaturated or aromatic 3-, 4-, 5-, 6- or 7-membered carbocycle; a heteroaryl fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; or an aryl fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle and further fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; a C5-C7 cycloalkenyl; a C5-C7 cycloalkenyl fused with a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle; or a saturated, partially or totally unsaturated or aromatic 4-, 5-, 6- or 7-membered heterocycle;R4, substituted or non-substituted by at least one T5, represents a linear or branched C2-C6 alkyl; a linear or branched C1-C6 fluoroalkyl; or a C3-C6 cycloalkyl;T1 independently represents a hydrogen atom, a halogen atom; an alkyl; —OH; —(X)x—C1-C6 alkyl; a linear or branched fluoroalkyl; a linear or branched —O—C1-C3 fluoroalkyl; —(X)x—C3-C6 cycloalkyl; —(X)x—(CT5T6)y-C3-C6 cycloalkyl; —(X)x—(CT5T6)y-aryl; —(X)x—(CT5T6)yCN; —(X)x—(CT5T6)yOT3; —(X)x—(CT5T6)yST3; —(X)—(CT5T6)yS(O)T3; —(X)x—(CT5T6)yS(O)2T3; —(X)x—(CT5T6)yNT3T4; —(X)x—(CT5T6)yC(O)T3; —(X)x—(CT5T6)yC(O)OT3; —(X)x—(CT5T6)yC(O)NT3T4; —(X)x—(CT5T6)yNT3C(O)NT3T4; —(X)x—(CT5T6)yNT3C(O)T4; —(X)x—(CT5T6)yNT3C(O)OT4; —(X)x—(CT5T6)yOC(O)NT3T4; —(X)x—(CT5T6)y S(O)2NT3T4 or (X)x—(CT5T6)yNT3S(O)2T4;T2 independently represents a hydrogen atom; a halogen atom; a linear or branched —O—C1-C3 alkyl; a linear or branched C1-C3 fluoroalkyl; a linear or branched O—C1-C3 fluoroalkyl; a linear or branched C1-C3 alkyl; or —CN; optionally two geminal T2 form with the carbon atom to which they are bonded, a C3-C7 cycloalkyl;X independently represents an oxygen atom; a sulphur atom; NT3; S═O or S(O)2;T3 and T4, identical or different, independently represent a hydrogen atom; a branched or linear C1-C6 alkyl; or a C3-C6 cycloalkyl; optionally T3, T4 and the nitrogen atom to which they are bonded form a C4-C6 heterocycloalkyl;T5 and T6, identical or different, independently represent a hydrogen atom; a fluorine atom; a linear or branched C1-C3 alkyl; or a C3-C6 cycloalkyl; optionally T5, T6 and the carbon atom to which they are bonded form a cyclopropyl;x independently represents 0 or 1;y independently represents 0, 1, 2 or 3; and a racemate, enantiomer, tautomer, atropisomer, diastereoisomer or a pharmaceutically acceptable salt thereof. |
