基于巨噬细胞迁移抑制因子之抑制作用的疾病治疗剂;THERAPEUTIC AGENT FOR DISEASE, BASED ON INHIBITION OF MACROPHAGE MIGRATION INHIBITORY FACTOR

摘要

一种由下列通式[1]表示之苯并哌喃(benzopyran)衍生物或其盐类，其结合至MIF，呈现MIF抑制效应，且适用于MIF之抑制具效用之疾病之治疗性或预防性治疗：;其中R 1 代表任意地经取代之C1-6烷基；R 2 及R 3 之一者代表氢原子；且R 2 及R 3 之另一者代表氢原子、任意地经取代之胺基、任意地经取代之醯基胺基、任意地经取代之胺甲醯基、或任意地经取代之芳基。; one of R 2 and R 3 represents a hydrogen atom; and the other of R 2 and R 3 represents a hydrogen atom, an optionally substituted amino group, an optionally substituted acylamino group, an optionally substituted carbamoyl group or an optionally substituted aryl group.