发明名称 |
PEPTIDE INHIBITORS OF BCR-ABL OLIGOMERIZATION |
摘要 |
In one aspect, the invention relates to peptides comprising the Bcr-Abl coiled-coil oligomerization domain and an alpha helix stabilizing moiety, mutant forms thereof, truncated forms thereof, derivatives thereof, and related peptides, which are useful as inhibitors of the Bcr-Abl chimeric protein; pharmaceutical compositions comprising the compounds; and methods of treating hyperproliferative disorders associated with Bcr-Abl using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
CA2944043(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
CA20152944043 |
申请日期 |
2015.03.25 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
LIM, CAROL;BRUNO, BENJAMIN J.;MILLER, GEOFFREY D.;DIXON, ANDREW S. |
分类号 |
A61K38/12;A61K38/48 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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