摘要 |
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome. |
申请人 |
ARRAY BIOPHARMA, INC. |
发明人 |
ALLEN, SHELLEY;BRANDHUBER, BARBARA, J.;KERCHER, TIMOTHY;KOLAKOWSKI, GABRIELLE, R.;WINSKI, SHANNON, L. |