发明名称 |
RECOMBINANT ADENOVIRUS WITH INCREASED SAFETY AND ANTICANCER ACTIVITIES, AND USE THEREOF |
摘要 |
The present invention relates to a recombinant adenovirus with increased in-vivo safety, tissue specificity, and anticancer activities, and a use thereof. Specifically, the recombinant adenovirus comprising: a promoter of the liver tissue-specific phosphoenolpyruvate carboxykinase (PEPCK) gene; a trans-splicing ribozyme which is operably linked to the promoter and acts on a cancer-specific gene; a therapeutic gene or a reporter gene which is linked to the 3' exon of the ribozyme; and a serotype 35 fiber knob and a serotype 5 shaft, in which the orf4 gene is deleted from adenovirus E1, E3 and E4 orf1, shows remarkable in-vivo safety, high specificity for a target tissue, and remarkable anticancer effects, and thus can be useful for an anticancer drug or a cancer diagnostic agent as a gene delivery vector. |
申请公布号 |
EP2924115(A1) |
申请公布日期 |
2015.09.30 |
申请号 |
EP20130857052 |
申请日期 |
2013.11.21 |
申请人 |
NATIONAL CANCER CENTER |
发明人 |
LEE, SANG-JIN;KIM, YUN-HEE;KIM, IN-HOO;LEE, SEONG-WOOK;JEONG, JIN-SOOK;HAN, SANG YOUNG |
分类号 |
C12N7/01;A61K35/76;C12Q1/02 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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