| 摘要 |
<p>The present invention provides a process for producing highly pure fluoro-compounds by making use of less costly and readily handleable N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products. Specifically the present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (1):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 R 2 R 3 COH€ƒ€ƒ€ƒ€ƒ€ƒ(1)
(wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R 2 and R 3 are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R 1 , R 2 and R 3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 1 R 2 R 3 CF€ƒ€ƒ€ƒ€ƒ€ƒ(2)
(wherein R 1 , R 2 and R 3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR 4 OH€ƒ€ƒ€ƒ€ƒ€ƒ(3)
(wherein R 4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.</p> |
