MODULATION OF THE PHOSPHATIDYLINOSITOL-3-KINASE PATHWAY IN THE DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS

摘要

Disclosed herein are cell cultures comprising differentiated human cells and methods of producing the same. The present invention provides compositions and methods for the production of differentiated human cells from human pluripotent cells. Preferably, the differentiated cells are selected from the group consisting of mesendoderm cells, definitive endoderm cells, ectoderm cells, trophectoderm cells, and extraembryonic endoderm cells.