发明名称 |
Histone Deacetylases Inhibitors |
摘要 |
New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where R<SUB>1 </SUB>is a linear or branched chain containing at least two conjugated double bonds, A is an optionally substituted phenyl or pyridyl ring, Ar is an aryl or heteroaryl group, and R<SUB>3 </SUB>is hydrogen or alkoxyalkyl. The application also describes the use of said compounds in the treatment of diseases associated to the deregulation of histone deacetylases activity, such as tumors, as well as the relevant pharmaceutical compositions for administration to patients requiring said treatment.
|
申请公布号 |
US2008096889(A1) |
申请公布日期 |
2008.04.24 |
申请号 |
US20050664187 |
申请日期 |
2005.09.30 |
申请人 |
MINUCCI SAVERIO;PELICCI PIER G;MAI ANTONELLO;BALLARINI MARCO;GARGIULO GAETANO |
发明人 |
MINUCCI SAVERIO;PELICCI PIER G.;MAI ANTONELLO;BALLARINI MARCO;GARGIULO GAETANO |
分类号 |
A61K31/165;A61K31/341;A61K31/381;A61K31/44;A61K31/4436;A61K31/5375;A61P35/00;C07C259/06;C07D213/46;C07D295/155;C07D307/54;C07D307/80;C07D333/24;C07D333/56;C07D409/06 |
主分类号 |
A61K31/165 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|