Genes with ES cell-specific expression

摘要

Probes for screening embryonic stem cells (ES cells) which contain DNA for genes encoding proteins expressed specifically in ES cells (ES cell associated transcript genes, ECAT genes) (A), are new. The sequences of 23 such genes of human and mouse origin are fully defined in the specification. Independent claims are also included for: (1) screening ES cells by analysis of the expression within the cell of the proteins encoded by one or more of the designated ECAT genes, using the probes containing them; (2) four of the ECAT genes and the proteins encoded by them; and (3) DNA sequences derived from (A) by addition, deletion and/or substitution of one or more bases. ACTIVITY : Cardiant; Neuroprotective. No biological data given. MECHANISM OF ACTION : Cell therapy.