| 摘要 |
A drug delivery device for regulating delivery of a drug to a patient provides a controlled rate of delivery which accounts for changes in health or required dose and, in systems with inherent lag, enables a rapid and accurate response whilst maintaining system stability. The device comprises a drug delivery or dose regulator; a sensor for measuring a biochemical or physiological property associated with the drug or the condition to be treated and generating a sensor signal; a controller configured to control the rate of delivery or dose of drug via the regulator in response to the difference in a measured biochemical or physiological property with respect to a target (an error), wherein the controller comprises an active control component for generating an active output signal in response to the error signal; and a manipulation component which manipulates the active output signal to generate a post-manipulation signal for communication to the regulator as a final output signal, characterized in that the controller further comprises an anti-wind up component for reducing or inhibiting the effect of signal wind up in the active control component; and/or the manipulation component comprises a filter sub-component for conditioning the active output signal, whereby the final output signal provides a controlled rate of delivery or dosage administered to a patient in response to the measured property. The invention finds particular advantages in the delivery of oxygen to patients receiving supplementary oxygen in a home oxygen therapy environment or in ambulatory, including emergency, environments. |
