发明名称 Method of preparation of 3-(1,3-Dihydroimidazole-2-thione-1-yl)-chromanes and thiochromanes as dopamine-beta-hydroxylase inhibitors
摘要 A process for the preparation of the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts of a compound of formula 1: where R 1 , R 2 and R 3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R 4 signifies hydrogen, alkyl or alkylaryl group; X signifies CH 2 , oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH 2
申请公布号 EP1911757(A2) 申请公布日期 2008.04.16
申请号 EP20070076124 申请日期 2003.10.10
申请人 PORTELA & CA., S.A. 发明人 LEARMONTH, DAVID ALEXANDER;SOARES DA SILVA, PATRICIO MANUEL VIEIRA ARAUJO;BELIAEV, ALEXANDER
分类号 C07D405/04;A61K31/4164;A61P9/00;A61P43/00;C07D233/84;C07D311/58;C07D335/06;C07D409/04;C07F7/18 主分类号 C07D405/04
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