| 摘要 |
The invention encompasses stable multiparticulate pharmaceutical compositions of tolterodine having at least one pharmaceutically acceptable excipient and at least two populations of multiparticulates each population having tolterodine or a salt thereof and the ratio of the populations is from 90:10 to 10:90 by weight, wherein after storage for 1 month at 40° C. and 75% relative humidity the difference between the dissolution profile at 4 hours is no more than about 5% when compared to the dissolution profile at the time of manufacture.
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