发明名称 |
Structure based alignment and clustering of proteins (STRALCP) |
摘要 |
Disclosed are computational methods of clustering a set of protein structures based on local and pair-wise global similarity values. Pair-wise local and global similarity values are generated based on pair-wise structural alignments for each protein in the set of protein structures. Initially, the protein structures are clustered based on pair-wise local similarity values. The protein structures are then clustered based on pair-wise global similarity values. For each given cluster both a representative structure and spans of conserved residues are identified. The representative protein structure is used to assign newly-solved protein structures to a group. The spans are used to characterize conservation and assign a "structural footprint" to the cluster.
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申请公布号 |
US2008033659(A1) |
申请公布日期 |
2008.02.07 |
申请号 |
US20070890863 |
申请日期 |
2007.08.07 |
申请人 |
ZEMLA ADAM T;ZHOU CAROL E;SMITH JASON R;LAM MARISA W |
发明人 |
ZEMLA ADAM T.;ZHOU CAROL E.;SMITH JASON R.;LAM MARISA W. |
分类号 |
G06F19/00;G01N33/48 |
主分类号 |
G06F19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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