HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR

摘要

A human antibody or an antigen-binding fragment which binds human IL-6 re ceptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity w ith an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6 R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.