| 摘要 |
The present disclosure relates to a delayed controlled release compositio n of at least one form of venlafaxine. According to the disclosure a delayed controlled release composition of venlafaxine hydrochloride is provided by a blend of polymers in the core formulation. The core formulation having ext ended release polymers is coated with a non-permeable polymer blend formed o f a water in-soluble polymer and an enteric coating polymer, which does not release the active drug in either acid or base for up to about 4 hours. Upon disintegration of the non-permeable coating the active drug is released in a sustained manner due to the polymers within the core formulation. The dela yed release prevents the substantial release of venlafaxine into the stomach .
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