发明名称 |
Transcriptional Intermediary Factor-2 |
摘要 |
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2. |
申请公布号 |
EP1865060(A1) |
申请公布日期 |
2007.12.12 |
申请号 |
EP20070101726 |
申请日期 |
1997.07.11 |
申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE LOUIS PASTEUR;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHAMBON, PIERRE;GRONEMEYER, HINRICH;VOEGEL, JOHANNES;LUTZ, YVES |
分类号 |
C12N15/12;C07K14/47;C07K16/18;G01N33/50;G01N33/566 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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