| 摘要 |
<p>A method of detecting oxidative stress-mediated Dehydroepiandrosterone (DHEA) formation in a test sample of human blood, body fluid or tissue comprising:
(a) treating said test fluid or tissue with an agent that produces oxidative metabolites in a control fluid or tissue, wherein the agent is selected from the group consisting of FeSO 4 , other Fenton reactants, and oxido-reducing agents,
(b) treating a control fluid or tissue with said agent, and
(c) determining whether the quantities of DHEA in the test sample and in the control sample rise in response to said treatment,
whereby a lack of response in the test sample relative to the control sample indicates that oxidative stress-mediated DHEA formation occurred previously in said test sample of body fluid.</p> |
