System for the Evaluation of Tracer Concentration in a Reference Tissue and a Target Region

摘要

The invention relates to the estimation of kinetic parameters for a target region ( 210 ) utilizing information from a normal (unperturbed) reference region ( 200 ). The proposed compartmental model models metabolic pathways for blood, reference and target tissue. The proposed analysis procedure features two alternatives: (A) Extraction of the plasma input in the reference region ( 200 ) and its unperturbed kinetic parameters, hereafter utilization of the plasma input and the kinetic parameters of the reference region as initial parameters for the analysis of the target region ( 210 ). (B) The system of kinetic equations describing the kinetics of the imaging agent in the target and reference regions is solved for the input function (amount of free imaging agent in the plasma or the total imaging agent SB(t) contained in plasma, blood elements and metabolites) considered to be the same for both regions.