YEAST Pichia pastoris X-33/2albumin STRAIN FOR SECRETION OF HUMAN ALBUMIN

摘要

FIELD: gene engineering, in particular yeast strain modified by introducing of foreign genetic material. ^ SUBSTANCE: claimed strain is obtained by transforming of starting culture Pichia pastoris X-33 with two albumin structural genes with signals of yeast alpha-factor secretion, transcribed under control of 5'AOX1 promoter and transcription termination region of hepatitis G virus. Strain of present invention is useful in production of albumin-containing drugs. ^ EFFECT: strain for production of human recombinant albumin of increased yield. ^ 3 ex