ACYLATED SINGLE CHAIN INSULIN

摘要

The invention is related to an acylated, single-chain insulin comprising the B- and the A-chain of human insulin or an analogue thereof connected by a connecting peptide, wherein a lysine residue being substituted for the natural amino acid residue in at least one of the positions A8, A9 or A10 in the human insulin A-chain is chemically modified by acylation.