摘要 |
The present invention provides for TLR agonist conjugates (compounds) and compositions, as well as methods of using them. The compounds of the invention are broad-spectrum, long-lasting, and non-toxic combination of synthetic immunostimulatory agents, which are useful for activating the immune system of a mammal, preferably a human and can help direct the pharmacophore to the receptor within the endosomes of target cells and enhance the signal transduction induced by the pharmacophore. |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CARSON, DENNIS, A.;TAKABAYASHI, KENJI;COTTAM, HOWARD, B.;CHAN, MICHAEL;WU, CHRISTINA, C., N. |
发明人 |
CARSON, DENNIS, A.;TAKABAYASHI, KENJI;COTTAM, HOWARD, B.;CHAN, MICHAEL;WU, CHRISTINA, C., N. |