| 摘要 |
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-ß peptide (Aß) in the brain. Aß is derived from amyloid precursor protein (APP) by ß- and ?-secretases. Apolipoprotein E receptor 2 (ApoER2) is a cell-surface receptor for apolipoprotein E. This study shows that ApoER2 interacts with Xl 1 a/ß proteins and that APP forms association with ApoER2 in the presence of Xl Is. Significantly, ApoE stimulates the production of Aß, and ApoE4 produced more Aß than ApoE2 or ApoE3, correlating with previous studies showing that individuals with the ApoE4 polymorphism were more prone to development of AD. Thus, ApoE binding to ApoER2 on cell surface stimulates the generation of Aß from APP. Antagonists that interfere with the ApoE-ApoER2 interaction are proposed for the treatment of AD. |
