Abstract Compositions comprising an emulsion and aluminum salt nano-/micro-particles surface stabilized with at least one surfactant are useful as immunological adjuvants. The emulsion of these compositions comprises at least one oil; at least one surfactant; a plurality of surfactant vesicles; optionally at least one sterol; and an aqueous phase. The present invention also provides vaccines comprising one or more antigens combined with the emulsion and surface stabilized aluminum salt particles of the present invention, or one or more antigens combined with non-ionic surfactant vesicles.
申请公布号
WO2007098186(A2)
申请公布日期
2007.08.30
申请号
WO2007US04470
申请日期
2007.02.22
申请人
NOVAVAX, INC.;SMITH, GAIL;SHENOY, DINESH B.;LEE, ROBERT W.