METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS

摘要

The present invention is directed to novel compositions and methods and their use in treating an autoimmune disorder or achieving tolerance to an antigen. More specifically, the present invention is directed to human immunoglobulin constructs for loading a delivered T cell epitope on to the surface of an antigen presenting cell for achieving tolerance to that delivered T cell epitope. The present invention may be applied to any T cell epitope mediated autoimmune disorder.