A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent

摘要

Methods are provided for drying a particle. Specifically, there is provided a spraydried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.