BIODEGRADABLE POLYMER COMPOSITE MATERIAL WITH CUSTOM-MADE TYPE OF COCKTAILED DRUG RELEASE PROPERTIES AND PREPARATION METHOD THEREOF

摘要

A biodegradable polymer composite material and a method for preparing the same are provided to obtain the composite material for cell therapy which is able to independently fast-release or sustained-release a drug according to cell cycle by maintaining the releasing time of at least two growth factors or the drug, thereby significantly increasing the biocompatibility and tissue regeneration capacity of the drug. The biodegradable polymer composite material is characterized in that a nano-particle consisting of a biodegradable polymer such as polylactic acid, polyglycolic acid, polycaprolactone and a copolymer of polylactic acid-glycolic acid and a first growth factor is coated on a fibrous support consisting of a water-soluble polymer and a second growth factor. The method comprises the steps of: (a) mixing a water-soluble polymer dissolved in an aqueous solvent with an aqueous solution of a second growth factor so as to prepare a spray solution; (b) preparing a mixture solution of a biodegradable polymer; (c) mixing a biodegradable polymer dissolved in an aqueous solvent with an aqueous solution of a first growth factor to prepare a composition for coating; (d) spraying the spray solution into the mixture solution of the biodegradable polymer to form fiber having a micro-size; and (e) spraying the composition for coating onto the fiber to coat it with nano-particles.